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Treatment of matrix DAOexpressing cells with dalanine but not lalanine also rendered Prx1 partially unreactive toward mmPEG 24 (Appendix Fig S4D and E)
Concurrently, DAG is believed to potentially activate protein kinase C (PKC), a family of enzymes believed to play significant roles in various cellular functions
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Research has documented MT-1s potent MC1R activation-driven melanogenesis in human and rodent melanocyte models , characterising dose-dependent cAMP elevation, MITF nuclear translocation, tyrosinase upregulation, melanin synthesis increases, and eumelanin versus phaeomelanin ratio shifts following MT-1 treatment
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