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notably, the proportion of patients with weight gain during the study was substantially higher in the placebo group

Costantino A, Maiese A, Lazzari J, Casula C, Turillazzi E, Frati P, Fineschi V

For psoriasis, the main expectations are gradual improvement in plaque burden and symptoms over months, often with concurrent improvement in energy, mood, and cardiometabolic risk profiles

The DAC variant, with a 5.8- to 8.1-day half-life, by contrast creates a permanent baseline and follows a different frequency logic