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Acta Botanica Croatica 72, 157168

the idiosyncratic response may be extreme sensitivity to low doses or extreme insensitivity to high doses of drugs

doi: 10.1186/s13195-017-0250-1 73 YassineH

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Not every patient achieves the weight loss targets they are hoping for, and a meaningful proportion of patients even on maximum doses do not reach the 1520% body weight reduction that clinical guidelines increasingly use as a benchmark for meaningful metabolic benefit

The FDA's concerns cite peptide manufacturing risks: incompletely characterised active ingredient, peptide fragments, degradation products, and impurities that the immune system may recognise as foreign