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doi: 10.3389/fendo.2023.1156952 83 WuHLiaoKLiYTanZZhouZZengCet al

Artificial cells, nanomedicine, and Biotechnology, 48(1), pp.854-866

Xenobiotica 45 (10), 921929

Because both semaglutide and tirzepatide share GLP-1 receptor activation as a core mechanism, a patient with suboptimal GLP1R receptor function may have a biological ceiling that neither drug can push past regardless of dose