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While DNA methylation may be age, gender, and cell-type specific, MTHFR polymorphism might not be always associated with hypomethylation of DNA

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Chitosan-based nanocarriers, with their cationic surface chemistry, ease of functionalization and demonstrated ability to enhance cellular uptake while complexing nucleic acids, represent a particularly attractive scaffold for engineering such multifunctional doxorubicin delivery systems tailored to the specific challenges of breast cancer [66, 67]