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By 2024, Ozempic had surpassed Trulicity, also approved for type 2 diabetes (not obesity) to make up the largest share of GLP-1 prescriptions and spending (39% in 2024)
Product Specifications: Composition: Water for Injection, USP with 0.9% (9 mg/mL) Benzyl Alcohol, NF (bacteriostatic preservative) Volume: 30mL per sterile vial Container Type: Type I borosilicate glass vial with sterile rubber closure and aluminum overseal pH: 4.5 7.0 (per USP monograph) Osmolality: Hypotonic (approximately 0 mOsm/kg) Sterility Assurance Level: 10 (terminal steam sterilization) Bacterial Endotoxin: Bacterial Endotoxins Test Particulate Matter: Complies with USP Particulate Matter specifications FOR RESEARCH USE ONLY
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Previous studies looking at GLP-1 drugs and the brain have suggested that the drugs may slow the loss of volume in the parts of the brain required for planning, memory, emotion and sensory integration
GLP-1 medicines may have anti-inflammatory effects Researchers are also studying whether GLP-1 medicines may directly affect immune cells and inflammatory pathways