If pigmentation persists, consulting a dermatologist is recommended for advanced treatments
The post-session flush typically lasts 1 to 4 hours
There is no evidence to suggest that Vitamin C reduces the effectiveness of isotretinoin
The safety profile is generally favorable, with most side effects being GI-related (nausea, constipation, diarrhea) that improve with time and gradual dose escalation
Such high GSSG concentrations are unlikely to occur in most subcellular compartments but could be reached in the secretory pathway or during titration experiments of transgenic cell lines with an upregulated GSSG transporter 35,63,64,77
In my practice, I view it as a complementary, not competitive, ingredient: a reasonable addition for women who cannot tolerate retinoids, or as part of a layered approach for those who can