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Topical application does not eliminate systemic absorption
Methods A total of 147 women with PCOS were randomly assigned into two groups: the combo group ( n = 72) received a combination of metformin, pioglitazone, and ALC (500 mg, 15 mg, and 1500 mg, respectively), twice daily
Peptides injected into the subcutaneous fat layer diffuse into nearby capillaries and lymphatic vessels, entering systemic circulation without exposure to proteases
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