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The evolving medication landscape underscores the importance of individualized treatment planning, integrating both pharmacological and behavioral interventions to support long-term recovery across substance categories
Tirzepatide (a GLP-1R/GIPR dual agonist), licensed by the MHRA as Mounjaro for type 2 diabetes and, subject to NICE guidance, for weight management in adults with obesity, achieved mean weight reductions of up to approximately 22% in the SURMOUNT-1 trial (NEJM 2022) a notable improvement over GLP-1R monotherapy
Optogenetic stimulation of GABA neurons can decrease local neuronal activity while increasing cortical blood flow
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gentle pressure with a clean gauze pad for several seconds is sufficient to minimize bruising