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Users with joint pain often notice functional improvements before the scale changes enough to explain them, because the anti-inflammatory effects of GLP-1 agonism provide benefit independent of weight reduction

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Figure 5 Sham treated IL-10 deficient mice (Sham-Co) kept in the conventional environment developed severe enterocolitis manifested with moderately severe pathological lesions (score 2.4 0.3) including infiltration of inflammatory and immune cells lamina propria, ulceration, and rectal prolapse when compared to those control littermates kept in transgenic environment (0.3 02, data not clown)

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It stimulates collagen, improves microcirculation, reduces inflammation, and supports hair follicle regeneration, making it one of the most advanced therapies in regenerative dermatology

PMID: 29730462