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Generally, healthcare providers start at a lower dosage to avoid severe nausea or gastrointestinal distress

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Aberrant activation of signaling pathways and therapeutic implications Taken together, the aberrant activation of signaling pathways such as PI3K-AKT-mTOR, MAPK, NF-B, TGF-, Wnt/-catenin, JAK/STAT, Notch, Hippo-YAP/TAZ, and GAS6/AXL contributes extensively to therapy resistance across cancer types (Fig

These effects make it useful for post surgical recovery research and chronic wound research

PMID 25117994