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Las guas de la American Diabetes Association (ADA) recomiendan considerar estos agentes tempranamente en el algoritmo de tratamiento, particularmente en pacientes con enfermedad cardiovascular establecida o alto riesgo cardiovascular, dado que algunos agonistas de GLP-1 han demostrado reduccin de eventos cardiovasculares mayores en ensayos clnicos

Using degraded medication may result in: Suboptimal blood glucose control in patients with type 2 diabetes Reduced weight loss efficacy for those using GLP-1 agonists for weight management Unpredictable dosing , as degradation may be partial rather than complete Patients with diabetes who suspect reduced medication efficacy should monitor their blood glucose more frequently and contact their GP or diabetes care team if they have concerns about medication storage or if their diabetes control deteriorates unexpectedly

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Weight loss, often associated with GLP-1 drugs, can sometimes lead to changes in vitamin D levels

Common step therapy requirements: Trying a lower-cost medication such as phentermine, topiramate, or bupropion/naltrexone (Contrave) Completing a structured weight management program Documenting a minimum period on the step drug with insufficient results Ask your provider to document any previous weight loss attempts in your chart