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Protein-tyrosine nitration is a post-translational chemical modification process for the highly selective non-enzymatic introduction of a nitro group (-NO 2 ) into the side chain by peroxynitrite (ONOO - ), a short-lived biomolecule generated by the rapid reaction of NO with superoxide radicals in vivo 40,41
Gram scale synthesis of specialized pro-resolving mediator 17(S)-HDHA using lipoxygenase enhanced by water-soluble reducing agent TCEP
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The therapeutic dose is 1 to 2 mg per day for a 70 kg adult
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