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Safety-wise, a panel of independent toxicologists reviewed this ingredient and concluded it to be safe in cosmetics in the present practices of use and concentration
Symptoms of vitamin B12 deficiency can vary widely and may include fatigue, weakness, pale skin, shortness of breath, neurological symptoms such as numbness or tingling in the hands and feet, difficulty walking, memory loss, and mood changes
Discontinue if: Significant adverse reactions occur, you achieve body composition goals, no response after 8-12 weeks at optimal dosing, medical contraindications develop, or pregnancy occurs
Full tissue remodeling continues for eight to twelve weeks or longer
Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids (National Academies Press, 2000)