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A meta-analysis of incident MACE in the Phase III tirzepatide clinical trial programme for type 2 diabetes revealed evidence for cardiovascular safety and numerically fewer MACE events in people randomised to tirzepatide therapy [126]
Januvia is not approved to be used for weight loss
The poor adherence to long term treatment with AOMs evident in clinical practices, requires the design of effective algorithms based on the pathophysiology of obesity, to provide the most effective long-term strategies for sequential treatment with different AOMs and other modalities for body weight maintenance
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A systems view of the vascular endothelium in health and disease
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