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The direct influence of the E4 allele on FA-related bioenergetics (i.e., the transport and use of metabolites, in this case FAs, for energy) within the cerebrovasculature requires further attention, specifically in E4 carriers because of their increased cerebrovascular vulnerability observed with age which could impair nutrient transport to the brain and affect proper neuronal and glial functioning (Ojo et al., 2021)
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The question is whether the marginal extra response justifies the marginal extra side effect risk and cost
Danesh, J., Collins, R., Appleby, P
That's not how we do it
Handb Exp Pharmacol 2010: 369405
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