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Although initially developed for oncology, PROTAC-based strategies are now being explored in cardiovascular disease, where selective degradation of pathogenic proteins could mitigate hypertrophy, fibrosis and heart failure progression
The replacement of GLP-1 (737) Lys 34 with Arg causes a two-fold reduction in the EC 50
Metabolic and cardiovascular adverse effects associated with antipsychotic drugs
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Injecting intramuscularly instead of subcutaneously
The pentadecapeptide structure provides moderate stability, but the compound still degrades through standard pathways when exposed to heat and moisture
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