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Myostatin normally binds ActRIIB ALK4/5 co-receptor recruitment SMAD2/3 phosphorylation SMAD4 complex nuclear translocation transcriptional upregulation of Atrogin-1/MAFbx (E3 ubiquitin ligase) and MuRF1, driving protein degradation and satellite cell quiescence

Dose ranges are often species- and model-dependent, with rodent studies using body-weight-normalized doses (mcg/kg or mg/kg) that may be substantially different from the fixed doses used in primate or pharmacokinetic models

To make sure the medicine is safe, pregnant and breastfeeding women should consult their doctor before using the medicine

& Koeffler, H

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Subgroup analysis by study duration indicated a significant reduction of WC and BFP in studies with a duration less than or equal to 12 weeks, while the changes in studies lasting more than 12 weeks were not statistically significant