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FDA-approved GLP-1 drugs are injections or oral medications that are designed to mimic the effects of GLP-1, a naturally occurring hormone that regulates blood sugar and appetite in the body

FIDELIO-DKD was a phase 3 trial of finerenone, in addition to standard of care, in participants with T2DM, moderately advanced CKD (mean baseline eGFR was 44 mL/min/1.73 m 2 with a median UACR of 852 mg/g) with the majority (87%) having macroalbuminuria [100]

doi: 10.1177/0960327120937329 129 AhmedZAAbtarANOthmanHHAzizTA

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Plasma samples were collected from mice after a 12-h fasting period