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Based on preclinical and limited clinical studies, berberine's primary metabolic effects appear to occur through activation of AMP-activated protein kinase (AMPK), an enzyme that serves as a cellular energy sensor

It is important to note, the above studies proving the efficacy of the drug were conducted using a high dose of 2.4mg, with less efficacy seen on lower doses (4,6)

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We also quantified liver fat and fibrosis using vibration-controlled transient elastography

Although no direct causal link has been proven in humans, Wegovy should be avoided in patients with a personal or family history of medullary thyroid carcinoma or MEN2 syndrome