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10.1016/J.REDOX.2019.101321 32 CassinaP.CassinaA.PeharM.CastellanosR.GandelmanM.De LenA.et al (2008)
The role of OS in ALS pathology, whether as a primary cause of disease or a secondary consequence, is now well recognized and many preclinical and clinical studies have consistently demonstrated that the disease is characterized by high levels of OS markers able to induce cellular damage, impaired cell signalling, and finally cell death [25, 86]
This type of regulatory activity could be particularly relevant in tissues where gas exchange and environmental exposure are constant variables
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Even more striking, 86% of participants on the 12 mg dose achieved normal liver fat levels (below 5%) at 24 weeks