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EV-associated Nef impairs the bloodbrain barrier, induces oxidative stress, promotes Alzheimers-like pathology, and contributes to axonal degeneration, whereas EV-associated Tat directly causes neurite shortening and neuronal death [59, 139, 148,149,150,151]
For storage and handling, lyophilized Epithalon should be stored at -20C and is stable for 24+ months under these conditions
These biochemical changes correlate directly with improved sperm quality measurements and pregnancy outcomes
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