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In a study of colon cancer cells, COX-2 expression and PGE2 synthesis were upregulated by the IGF-2/IGF-1R autocrine pathway and IGF-1R blockade decreased COX-2 activity and inhibited tumor cell proliferation and promoted apoptosis (103)
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is supported by funds from the Ministry of Education and Science of Poland within the project 'Excellence Initiative - Research University', the Ministry of Health of Poland within the project 'Center of Artificial Intelligence in Medicine at the Medical University of Bialystok', the Medical Research Agency within the project 'Regional Center for Digital Medicine at the Medical University of Bialystok' (grant number 2023/ABM/02/00008), and the American Diabetes Association grant 11-22-PDFPM-03
171 In a placebo-controlled trial in 75 healthy male adolescents, 28 days of supplementing with 250 mg or 500 mg of citicoline daily led to increased attention and reaction speed and decreased impulsivity
14 In the stomach, GLP-1 agonists slow gastric emptying
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