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The glucagon arm appears to contribute substantively to body-composition outcomes (favouring fat-mass reduction) without offsetting the glycemic outcomes of the GLP-1/GIP arms (PMID 39515565, PMID 40609566)
Losing a significant percentage of lean mass especially for people over 50 accelerates the functional decline associated with aging and increases fall risk
Additionally, the speed of semaglutide-induced weight loss often 1-2 pounds per week doesnt allow sufficient time for gradual skin remodeling that might occur with slower weight reduction
Phosphorylation of the aggregate-forming protein alpha-synuclein on serine-129 inhibits its DNA-bending properties Dent SE et al
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The non-genomic effects are seen through a cascade of events including secondary messengers [9, 10] (Fig
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