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The sleep deprivation rat model of mania induces hyper-locomotion, increased sleep latency, and reduced hippocampal cell proliferation, with markers of pkc overactivity such as excess phosphorylated hippocampal and prefrontal synaptosomal-associated protein 25 (SNAP-25)
Long half-life (characterized in studies): Reported as long-acting in preclinical and clinical research, supporting extended-interval dosing within those study protocols
& Eldar-Finkelman, H
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