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Step-down frameworks hold each lower dose for 8 to 12 weeks

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High-dose use While trials have tested up to 1200mg/day (even as high as 2400mg/day) and illustrated safety, some report higher rates of gastrointestinal side effects, dizziness, and skin reactions at these levels.14 28 38 Additionally, these higher doses are often short-term (35 weeks) and used under clinical supervision

Amino acid conjugation is catalyzed by enzymes specific to each amino acid

doi:10.1111/dom.12993

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