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This shift in body composition can positively affect testosterone levels, as excess body fat is associated with lower testosterone

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Whether a prescription is on-label or off-label depends entirely on the patients individual weight criteria

Retrieved 11 October 2015

Conventional medicines have been discouraged due to their adverse effects and withdrawal symptoms

For many patients, the clinical benefits of GLP-1sparticularly sustained weight loss and metabolic improvementsare closely tied to continued use.[166] Once treatment is discontinued, individuals often experience weight regain and the return of obesity-related health conditions, underscoring the need to view obesity as a chronic condition that may require long-term treatment.[167] Adherence is also influenced by treatment tolerability.[168] While GLP-1s are generally well tolerated, side effects such as gastrointestinal symptoms and the inconvenience of regular self-injections may deter adherence for certain patients.[169] Recognizing the challenges associated with long-term adherence, pharmaceutical companies are innovating through the development of more-convenient delivery methods