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0.1% (placebo) Steady State: Achieved after 4-5 weeks of weekly dosing Safety: Nausea (68% at 4.5 mg), vomiting (32%), generally mild-moderate and transient Discontinuation: 14% discontinued due to GI adverse events Appetite Effects: Significant reductions in Visual Analogue Scale (VAS) hunger scores Publication: Lau DCW, et al

The main considerations are ensuring adequate nutrition as appetite decreases, monitoring reproductive hormones during treatment, and avoiding use if planning pregnancy in the immediate term

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Pathogenesis of hepatic encephalopathy: role of ammonia and systemic inflammation