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The one human trial that will measure tolerability directly has not started reporting it is only recruiting (planned 2026), studies a topical gel on small standardized wounds , and lists safety as a secondary, not primary, outcome (NCT07437586)
Research in immunodeficiency contexts has examined the relationship between glutathione availability and immune response capacity though translating that to healthy-population supplementation claims is a stretch the research doesnt fully support yet
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This does not, therefore, suggest an increase in autophagy flux, and could be due to an accumulation of autophagosome membranes or a block in the later stages of autophagy ( Interestingly, the same pattern was shown in Wolbachia -free C6/36 cells and SF-9 cells (Figure 2B and Supplementary Figure S1B)
If this occurs, the therapy is slowed down to accommodate
Healthy B12 levels can be sustained with monthly supplementation
