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This difference is no longer significant after bariatric surgery (167, 168)

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This was shown in a study with a single dose of 0.5 mg semaglutide in patients with different degrees of renal impairment (mild, moderate, severe, ESRD) compared with subjects with normal renal function

Clinical trials show average weight reduction of 1522% of body weight over 68 weeks significantly beyond what diet and exercise alone typically produce for most patients

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