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A groundbreaking study published in Nature one of the worlds most prestigious scientific journals by Ohno T et al

To ensure that [] weight reduction is caused primarily by a reduction in fat content, not lean body mass, a representative sample of trial subjects should have a baseline and follow-up measurement of body composition by DXA or a suitable alternative. When undue muscle loss becomes a problem Sarcopenia, the progressive, aging-related loss of muscle, contributes to the development of physical frailty, including weakness, fatigue and balance problems which limit a persons mobility and increase the risk of falls, fractures and other serious injuries

& Horvath, S

Gillespie AL, Calderwood D, Hobson L, Green BD

Nausea, constipation, and other gastrointestinal symptoms are most common during dose increases, and the same gradual titration schedule is used to manage this