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Inject tirzepatide into subcutaneous tissue (the layer of fat beneath the skin) on your abdomen, thigh, or upper arm using a short, thin needle appropriate for subcutaneous injection

[9] GLP-1 medications can significantly extend this timeline, with studies showing substantial prolongation of gastric emptying, particularly during initial therapy

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The abdomen's large surface area allows for extensive site rotation within a single anatomical region, which is particularly valuable for weekly injections over months or years