Common step therapy requirements include: Step 1: Metformin (must try for 3-6 months) Step 2: Another oral diabetes medication (sulfonylurea, SGLT2 inhibitor) Step 3: GLP-1 medication like Ozempic If youve already tried these medications, document the dates, doses, and why they were inadequate (side effects, insufficient blood sugar control, etc.)
[1] The MHRA has issued guidance regarding the risk of pancreatitis with GLP-1 receptor agonists, and whilst rare, this serious adverse effect requires immediate medical attention
The drug delivers a mean weight loss of around 15% with consistent tolerability, supporting long-term adherence and prescriber confidence
This can impact plaque buildup in arteries
Retatrutide isnt legally available in the UK, so it isnt a current option
When to Seek Immediate Medical Attention