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The compound has become one of the most recognised peptides within modern research literature due to its defined molecular structure, reproducible analytical profile and extensive use in experimental peptide investigations
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Future GLP-2 trials in IBD should stratify patients by disease phenotype (mucosal UC, inflammatory CD, stricturing CD) and incorporate serial cross-sectional imaging to monitor for stricture progression, given the mechanistic link between GLP-2R signaling through subepithelial myofibroblasts and intestinal fibrogenesis
MC1R affinity is therefore roughly an order of magnitude higher than at the other three subtypes, a preference rather than selectivity in the strict pharmacological sense
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