This is due to the inhibition of DNA synthesis (specifically purines and thymidine)
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The 28-day limit is therefore a safety margin that accounts for cumulative contamination risk across multiple punctures, not a reflection of preservative chemical degradation
Buying AHK-Cu in the larger size can also reduce the number of times a lab needs to reconstitute from a fresh vial, which some researchers prefer for consistency across a study
Protein studies also require stringent contamination control to ensure experimental reliability