GLP-1 receptor agonists such as liraglutide, semaglutide, and dulaglutide have shown significant reductions in major adverse cardiovascular events (MACE), including cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke, primarily in people with established cardiovascular disease or high cardiovascular risk
On the basis of liraglutide, semaglutide replace Lys with Arg at 34 position, replace Ala with 2-aminoisobutyric acid (AIB) at 8 position, and conjugate Lys with 18 carbon fatty acid chain at 18 position
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It has shown potential for supporting the management of chronic gastrointestinal conditions, such as inflammatory bowel diseases (IBD), including ulcerative colitis (UC)
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