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Mice born with liver-specific deletion of Gclc (using a Gclc f/f Albumin-Cre mouse strain) undergo liver failure and die shortly after birth 30

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Human studies have shown that the shift of fat storage from subcutaneous to visceral adipose tissue is associated with liver damage [12, 14] and the expansion of visceral adipose tissue may be a powerful predictor for NAFLD

In this study, the semaglutide-metformin combination showed that although no significant difference was observed in overall weight loss between the semaglutide-intensified and standard treatment groups, BMI, waist circumference, hip circumference, and body fat percentage were significantly lower in the semaglutide-intensified group