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A vitamin B12 deficiency can develop slowly and symptoms may include: Persistent tiredness or low energy Shortness of breath Pale skin Pins and needles Memory or concentration difficulties If left untreated, deficiency can lead to more serious neurological complications

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Most Common B12/MIC Side Effects If irritation continues to occur, apply an over-the-counter itch cream, preferably with hydrocortisone, or discontinue use entirely

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As a statement made by one of the leaders in vitamin B12 field more than 10 years ago, Carmels idea of cobalamin deficiency should not be diagnosed unless megaloblastic changes are found is still followed by many physicians and health authorities when accepting B12 deficiency diagnosis.1 But as time goes by, evidence and clinical cases showed that B12 deficiency symptoms can be seen even when B12 level in blood is within the reference range, as 200 900 pg/mL in the United States,2 and 135-650 pmol/L in Australia.3 In clinical practice, signs and symptoms of B12 deficiency start when plasma B12 levels are normal, and long historical studies showed that neurological symptoms of deficiency occur in patients without sign of anaemia