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These effects are especially important with respect to treatment of hedonic overeating in obesity, a more recent indication of GLP1-R agonists [30, 31]
Pilot clinical studies and case reports describe nausea in 65% of subjects at doses above 0,5 mg (resolution 2-4 h post-injection), flushing in 55%, transient increases in blood pressure and tachycardia in 40-60% of subjects, with peak acute effects occurring 90-120 minutes post-dose
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Discussion The present initial results revealed no statistically significant difference between the EGCG and placebo groups in any of the anthropometric, glycemic, lipid or hormone peptide variables assessed
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