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SURMOUNT-MAINTAIN (Horn 2026, 112 weeks): continued top dose -21.9% vs 5 mg step-down -16.6% vs placebo -9.9%, rescue therapy 8/25/67%: Aronne JAMA 2024
Taking progress photos and maintaining brief daily notes helps identify changes that accumulate slowly
Researchers have explored its relationship to markers of blood flow, vessel behavior, and inflammatory balance in experimental settings.*1-8,11
The most common side effect is temporary pain, swelling, or discomfort at the injection site
However, the IM route was the top-ranked statistically, followed by the SL and then the oral routes, but without clinical significance
