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GLP-1 is degraded rapidly by the ubiquitous enzyme dipeptidyl-peptidase IV (DPP-4)

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This includes nausea, diarrhea, vomiting, constipation, and decreased appetite

The hypothalamic-pituitary-ovarian axis is particularly sensitive to energy availability and metabolic status

for generalised pruritus, non-sedating antihistamines such as cetirizine or loratadine and unperfumed emollients may provide relief