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Further analysis suggested that the peptide may have increased the ratio of Bcl-2/Bax, and potentially decreased cleaved caspase-3 and PARP levels, two markers of cell death

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This would lead to the accumulation of senescent cells, the persistence of their pro-inflammatory SASP, and the chronic inflammation and tissue disruption seen in the disease, further reinforcing the pathological cycle

Hormonal-Inflammatory Regulation: Thyroid dysfunction, polycystic ovarian syndrome (PCOS), and insulin resistance are often coexisting conditions that exacerbate hair loss

PoppW.VahrenholzC.PrzygodaH.BrauksiepeA.GochS.MllerG.SchellC.NorpothK.1994DNA-protein cross-links and sister chromatid exchange frequencies in lymphocytes and hydroxyethyl mercapturic acid in urine of ethylene oxide-exposed hospital workers.665(1994),325332,0340-0131 90

Liu et al., 2013