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A Nature Communications study found that exercise raised the body's own MOTS-C in a small group of healthy men

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Mild fatigue during adjustment Initial fatigue or brain fog may occur during the first few days as the brain undergoes structural remodeling

Phase I safety studies show good tolerability without severe adverse events

Although rare, serious side effects have been noted, with gallbladder disease and pancreatitis among the most concerning

Cell-Derived Extracellular Matrix: Basic Characteristics and Current Applications in Orthopedic Tissue Engineering