Multiple randomized controlled trials including the SUSTAIN series demonstrate that GLP-1 therapy improves HOMA-IR (a measure of insulin resistance) and fasting insulin levels independent of weight loss alone
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The first cohort comprised individuals who started and continued either a GLP-1 receptor agonist or DPP-4 inhibitor for the first time between January 1, 2007, and December 31, 2020
The SURMOUNT-1 Three-Year Study The longest completed tirzepatide trial to date is the SURMOUNT-1 study, which followed participants for 176 weeks, approximately three and a half years
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