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Nature (2018) 555:6737
In safety management, severity and reversibility carry weight equal to frequency
Beyond detoxification, the antioxidant machinery functions as a redox-sensitive signaling platform, mediating post-translational modifications and transcriptional reprogramming that fine-tune stress responses
Metabolic rate decreases beyond what the lost weight alone would predict, a phenomenon called adaptive thermogenesis
Should there be any changes in diet or physical activity while taking these medications
It can be dephosphorylated and recycled back to the cell surface, ready to signal again
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