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Compared with individuals in the metformin and second- or third-line glucose-lowering medications groups, major CVEs were significantly lower in individuals with NAFLD and type 2 diabetes who received GLP-1RAs but not different from those who received SGLT2 inhibitors
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Historical reason: the original 503A and 503B compounding pharmacies that started compounding semaglutide in 2022 used B12 as a "marker" so patients and providers could visually distinguish their compounded product from FDA-approved Ozempic, which is always clear
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