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Mitochondrial dysfunction in Kupffer cells plays a central role: IR causes Kupffer cell mitochondria to release mtDNA and ROS, activating NLRP3 inflammasomes which then release IL-1 that amplifies neutrophil recruitment (199)
Acetylcarnitine also rapidly induces mGlu2 receptor expression through epigenetic mechanisms, resulting in antidepressant and analgesic effects [40, 106]
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Stojceska, A
In addition, L-carnitine has been shown to have anti-aging properties
