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CKB is induced by cAMP signaling in mouse and human adipocytes and adipose-selective deletion of CKB reduces thermogenic capacity and predisposes to obesity

Safety considerations: GLP-1 receptor agonists are contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

Our findings show that SGLT2 inhibitors appear more effective in reducing cardiovascular events in older people, and this may be one piece of information that clinicians can take into account when deciding with individual patients what is best for them. Our findings also suggest that clinicians should not be put off by smaller changes in blood sugar in older people, as the cardiovascular benefits were greater despite a smaller improvement in blood sugar, he added.

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v) OR was not provided or could not be converted into OR (RR, rate difference, HR) and its 95% confidence interval

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