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The Lau monotherapy data cuts through that by showing the amylin analog producing double-digit weight loss entirely on its own, which is the cleanest argument that adding it to a triple agonist brings genuinely additive firepower rather than redundant signalling

Cardiovascular disease in a nationwide population of danish women with polycystic ovary syndrome

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These findings are far from conclusive

The impact even extends to autism spectrum disorder (ASD), where P.g administration disrupts oral and gut microbiota, leading to metabolic disturbances (reduced SCFAs, accumulation of 3-phenylpropionate) and exacerbation of ASD-like behaviors (Li et al., 2025)

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