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The dedicated cardiovascular trial did not find excess major events and reported lower all-cause mortality, but resting heart rate remains a titration marker rather than a one-time measurement. How to Titrate, and the Cost of Going Too Fast The final dose shapes the endpoint, but escalation speed is the largest modifiable driver of side effects

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Tirzepatide population pharmacokinetics and exposure Schneck 19-study pooled popPK (CL/F 0.061 L/h, half-life 5.4 d, accumulation 1.7x, body-weight covariate +22% at 70 kg / -33% at 120 kg)

Journal of Inflammation Research, 5, 67-77

The evidence base consists primarily of preclinical studies in animal models, with limited clinical data in humans

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